Kate & Humphrey and their 3 wolf cubs (Stinky, Claudette and Runt) are happily preparing to celebrate their first winter together when their smallest cub, Runt, mysteriously disappears. They must now go on a new journey across the wilderness to find and bring back Runt before the winter snows block their way home. While their adventure does not end exactly as planned, Kate & Humphrey discover that "Home is where the Family Is."